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Adults seeking the strongest available weight-loss outcome in a brand-name SKU Adults with obesity and moderate-to-severe OSA (cross-listed indication) Adults with pre-diabetes and obesity who want T2D progression prevention Clients who plateaued on a semaglutide SKU and want a tirzepatide trial Clients comfortable with weekly subcutaneous injection In SURMOUNT-5, a 72-week head-to-head trial sponsored by Eli Lilly, adults on Zepbound (tirzepatide) achieved 20.2% mean body weight loss, compared with 13.7% for adults on Wegovy (semaglutide)

Because of this potential concern, individuals with a personal or family history of thyroid cancer or endocrine tumors are generally advised against using semaglutide